Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury
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چکیده
منابع مشابه
Targeting Toll-Like Receptor 2 in Ischemia/Reperfusion Injury
Coronary heart disease is an inflammatory disorder of the coronary vessels. With a prevalence of approximately 20% in the general population, it is an endemic problem in industrialized countries. It has been the leading cause of death in the past 80 years or so in the United States. Coronary heart disease may lead to acute coronary syndromes. These cover a wide spectrum of clinical presentation...
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PURPOSE We investigated whether retinal ischemia and inflammation produced by raising the intraocular pressure above normal systolic levels differs in mice that lack a functional toll-like receptor 4 (Tlr4) signaling pathway. METHODS In this work we used the murine strain B6.B10ScN-Tlr4(lps-del)/JthJ, which does not express functional Tlr4. C57BL/6J was considered as the control. We induced r...
متن کاملInhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury.
BACKGROUND We previously reported that the functional mutation of Toll-like receptor 4 (TLR4) in C3H/HeJ mice subjected to myocardial ischemia-reperfusion (MI/R) injury resulted in an attenuation of myocardial infarction size. To investigate the ligand-activating TLR4 during MI/R injury, we evaluated the effect of eritoran, a specific TLR4 antagonist, on MI/R injury, with the goal of defining b...
متن کاملToll-like Receptor 2 Modulates Left Ventricular Function Following Ischemia-Reperfusion Injury Running Head: TLR2 and ischemia-reperfusion injury
1Department of Medicine, Winters Center for Heart Failure Research, 2Texas Heart Institute at St. Luke’s Episcopal Hospital, 3Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, and Texas Children’s Hospital, Houston, TX, , 4Laboratory of Biomedical Science, North Shore University Hospital, New York University School of Medicine, Manhasset, NY, 5Department of H...
متن کاملToll-Like Receptors and Myocardial Ischemia/Reperfusion, Inflammation, and Injury
Cardiac ischemia/reperfusion (I/R) injury occurs in several important clinical contexts including percutaneous coronary interventions for acute myocardial ischemia, cardiac surgery in the setting of cardiopulmonary bypass, and cardiac transplantation. While the pathogenesis of I/R injury in these settings is multifactorial, it is clear that activation of the innate immune system and the resulta...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2009
ISSN: 0270-9139
DOI: 10.1002/hep.23365